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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCYT1A All Species: 44.24
Human Site: T118 Identified Species: 69.52
UniProt: P49585 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49585 NP_005008.2 367 41731 T118 G V C S D E L T H N F K G F T
Chimpanzee Pan troglodytes XP_001143741 320 37092 G93 P N S Y L L V G V C S D D L T
Rhesus Macaque Macaca mulatta XP_001090055 338 38695 G111 P N S Y L L V G V C S D D L T
Dog Lupus familis XP_535776 367 41764 T118 G V C S D E L T H N F K G F T
Cat Felis silvestris
Mouse Mus musculus P49586 367 41648 T118 G V C S D E L T H N F K G F T
Rat Rattus norvegicus P19836 367 41662 T118 G V C S D E L T H N F K G F T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517894 294 33692 C66 R Y D A V Q H C R Y V D E V V
Chicken Gallus gallus XP_422725 367 42078 T118 G V C S D E L T H N F K G F T
Frog Xenopus laevis NP_001089299 367 41920 T118 G V C S D E L T H N L K G F T
Zebra Danio Brachydanio rerio NP_001018571 359 41135 T115 G V C S D D L T H K F K G F T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_647621 526 58183 T247 G V C N D E L T H R M K G R T
Honey Bee Apis mellifera XP_395764 403 46370 T155 G V C N D Q L T H S K K G R T
Nematode Worm Caenorhab. elegans P49583 362 41751 T122 G V C G D R D T H K Y K G R T
Sea Urchin Strong. purpuratus XP_001180754 425 48260 T134 G V C N D E L T H R N K G N T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13259 424 49388 T145 G V P S D K I T H K L K G L T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 58.5 60.7 96.4 N.A. 96.1 96.4 N.A. 77.3 89 86.3 76.2 N.A. 36.1 46.4 37.8 45.4
Protein Similarity: 100 69.2 71.6 98 N.A. 97.5 97.2 N.A. 78.1 95 91.2 84.1 N.A. 46 62 52.3 60
P-Site Identity: 100 6.6 6.6 100 N.A. 100 100 N.A. 0 100 93.3 86.6 N.A. 73.3 66.6 60 73.3
P-Site Similarity: 100 13.3 13.3 100 N.A. 100 100 N.A. 13.3 100 93.3 93.3 N.A. 80 86.6 66.6 80
Percent
Protein Identity: N.A. N.A. N.A. N.A. 34.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 60 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 74 0 0 0 0 7 0 14 0 0 0 0 0 % C
% Asp: 0 0 7 0 80 7 7 0 0 0 0 20 14 0 0 % D
% Glu: 0 0 0 0 0 54 0 0 0 0 0 0 7 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 40 0 0 47 0 % F
% Gly: 80 0 0 7 0 0 0 14 0 0 0 0 80 0 0 % G
% His: 0 0 0 0 0 0 7 0 80 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 7 0 0 0 20 7 80 0 0 0 % K
% Leu: 0 0 0 0 14 14 67 0 0 0 14 0 0 20 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % M
% Asn: 0 14 0 20 0 0 0 0 0 40 7 0 0 7 0 % N
% Pro: 14 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 14 0 0 0 0 0 0 0 0 0 % Q
% Arg: 7 0 0 0 0 7 0 0 7 14 0 0 0 20 0 % R
% Ser: 0 0 14 54 0 0 0 0 0 7 14 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 80 0 0 0 0 0 0 94 % T
% Val: 0 80 0 0 7 0 14 0 14 0 7 0 0 7 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 14 0 0 0 0 0 7 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _